10, Issue. Systemic Lupus Erythematosus (SLE) is an autoimmune disease mostly affecting women of childbearing age (Gergianaki et al., 2018). Journal Name: Current Pharmaceutical Design. Immunol Med. Keywords: systemic lupus erythematosus, neuropsychiatric lupus, fingolimod, choroid plexus, RNA-seq Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoreactive B and T lymphocytes, the overproduction of autoreactive antibodies, and tissue deposition of immune complexes. Clipboard, Search History, and several other advanced features are temporarily unavailable. Introduction (2) (SLE). Neuropsychiatric manifestations in SLE are difficult complications that may cause substantial impairment of quality of life as well as disability. Ann Rheum Dis 58: 85 – 89, . Although the underlying mechanisms are still largely unraveled, several … This suggests that systemic lupus erythematosus (SLE) is more common in elderly people than was originally thought and is a potentially treatable cause of organic brain disorder. Abstract. The Egyptian Rheumatologist, Vol. Dantzer R. Neuroimmune Interactions: From the brain to … Patients with SLE and … -, Rönnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Neuropsychiatric lupus: the prevalence and autoantibody associations depend on the definition: results from the 1000 faces of lupus cohort. A breakthrough study demonstrated that type I interferon (IFN) activates microglia, which then engulf synaptic material, leading to cognitive impairment. To this end, murine models represent our best resource to investigate pathogenesis of central nervous system (CNS) lupus, and potentially develop new drugs. Neuropsychiatric manifestations are commonly found in patients with SLE and are an important cause of morbidity and mortality in these patients ().However, for many years, lack of consensus in defining neuropsychiatric syndromes in systemic lupus erythematosus (NPSLE) presented a major obstacle in their research. 2001;194(12):F59–F63. Central nervous system damage, a major organ manifestation of systemic lupus erythematosus (SLE), causes significant morbidity and mortality. Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. ↵ Mok CC, Lanchbury JS, Wai Chan D, Sing Lau C (1998) Interleukin-10 promoter polymorphisms in southern Chinese patients with systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is an autoimmune disease that affects the skin and musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, … Systemic lupus erythematosus (SLE) is charac- terized by the presence of several autoantibodies, including anti-dsDNA antibodies [1,2]. Borowoy AM, Pope JE, Silverman E, Fortin PR, Pineau C, Smith CD, Arbillaga H, Gladman D, Urowitz M, Zummer M, Hudson M, Tucker L, Peschken C. Semin Arthritis Rheum. Muslimov IA, Iacoangeli A, Eom T, Ruiz A, Lee M, Stephenson S, Ginzler EM, Tiedge H. J Neurosci. Arthritis Rheum 41: 1090 – 1095, . During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Background: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder characterized by multiple affected systems. NPSLE is associated with increased morbidity and mortality. Rheumatology (Oxford). Med. 2015 Sep;67(9):1237-1245. doi: 10.1002/acr.22589. In 1999, the American College of Rheumatology (ACR) research committee published a set of case definitions for neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations, 1 which involve the central and the peripheral nervous system and that range from overt manifestations such as stroke, seizures and psychosis, to more subtle abnormalities of cognitive function (see supplementary … To facilitate the process of attribution, a number of “attribution models” have been proposed, most recently by the Italian Study Group on NPSLE. 2019 Aug 19;11(8):e5424. Experts discuss the increasing use of telemedicine in rheumatology during the COVID-19 pandemic. NIH Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Central nervous system manifestations of systemic lupus erythematosus (CNS lupus) describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus (SLE) in the central nervous system (CNS). Dis. Key words: Systemic lupus erythematosus, Multistate modeling, Neuropsychiatric. In 1999, a classification criterion for NPSLE has been developed by the American College of Rheumatology (ACR), which included case definitions for 19 neuropsychiatric syndromes, significant exclusions, and recommendation of ascertainment [ 6 ]. Aseptic Meningitis and Depression: The Neuropsychiatric Manifestations of a Patient with Systemic Lupus Erythematosus. 2020 Aug;222:58-72. doi: 10.1016/j.schres.2020.05.036. This is recommended in focal manifestations, such as strokes and transient ischemic attacks. Nature Reviews Neurology, Vol. In the last decades, the rate of successful pregnancies for these women has greatly increased, thanks to the general improvement in SLE management, but also to the availability of drugs compatible with pregnancy and lactation ( Lazzaroni et al., 2016 ). When a non-thrombotic manifestation is accompanied by the persistent presence of aPL antibodies at moderate-to-high titers, antiplatelet therapy only is sufficient. Clin. She was switched from intravenous cyclophosphamide (IV CYC) to rituximab in 2003. Rheum. This is not only a theoretical matter of taxonomy, but also a determinant of the therapeutic plan. Hirohata S, et al. Indeed, there is a dearth of serologic, imaging, or immunologic biomarkers to verify the presence and course … Application of Plasma Exchange in Steroid-Responsive Encephalopathy. 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