Type here to filter the list. - And More, Close more info about Expert Insights on Psoriatic Arthritis From ACR Convergence 2020. … - Conference Coverage What was reported at the ACR 2020 meeting was the effect of guselkumab on axial disease in PsA. There are some really interesting poster and abstract presentations on spondyloarthritis at the ACR Convergence 2020. Abstract Supplement ACR Convergence 2020. November 5-9, 2020… Program and Faculty are updated daily - check back often for the most up-to-date information. The SELECT – PsA 1 study also included adalimumab as a comparator. We would like to show you a description here but the site won’t allow us. Two long-time Brigham rheumatologists also received prestigious honors. These data were presented earlier at EULAR 2020, but this was the first time they were presented at ACR. If a patient has not responded to treatment with 1 or more TNF inhibitors, then I would probably use IL-17 inhibitors first, only because they have a longer track record compared to the JAK inhibitors. At the ACR Convergence 2020, updated findings were presented for weeks 52 to 92 in patients who continued ADL-PF (N = 552). A phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the novel tyrosine kinase type 2 (Tyk2) inhibitor deucravacitinib and was presented in a late-breaking abstract at ACR 2020.6 Tyk2 is part of the Janus kinases. Investigators said efficacy response rates at week 78 were 84.2% for all patients, and 83.4%, 85.8%, and 84.3% for the biosimilar, week 26 switch, and week 52 switch groups, respectively. Minimal disease activity with filgotinib was found to be about 31% at week 100.3. Important Dates . All Days; Fri, Nov 6 ; Full Schedule - 2020 ACR Convergence. Investigators examined whether iCMP was effective at decreasing the incidence rates of ED visits, hospitalizations and outpatient appointment no-shows. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. These cells are highly activated and are equipped to kill target cells. The work provided promising evidence that targeting this pathway could be a novel therapeutic strategy for both systemic and joint-based RA-induced bone loss. Guselkumab, an interleukin (IL)-23 p19 inhibitor, has been effective in PsA, as demonstrated by the results of phase 2 and phase 3 studies published in the Lancet. A couple of head-to-head studies were published in the past year, although not presented at ACR 2020, which compared ixekizumab vs adalimumab and secukinumab vs adalimumab. So, this is another new and interesting class of drugs that we can look forward to. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 0403. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. Presented at: ACR Convergence 2020; November 5-9, 2020. Posted on 10/27/2020 0 . Importantly, exceedingly few potentially eligible patients were eliminated by screening using this algorithm. A nurse-led integrated care management program (iCMP) aims to coordinate medical care and to uncover and address social determinants of health-related needs for medically and psychosocially complex patients at high risk for frequent emergency department visits and hospitalizations. However, we do have a biomarker, and that is skin psoriasis. This totals to up to as many as 12 different targeted novel molecules that we have for the treatment of PsA, so it has become a fairly rich field of treatment options besides the usual conventional synthetic DMARDs. Abstract 2025. The study revealed a unique population of CD38hi CD8+ T cells that accumulated in the joints of patients with inflammatory arthritis following anti-PD-1 therapy. GRAPPA is working on their treatment guidelines, which are expected to be released at the end of 2021. ET. “We hope that by understanding the similarities and differences between immune cells in different types of inflammatory arthritis, including checkpoint inhibitor-associated arthritis, we can identify specific signals that block the key pathologic signals in each condition,” Dr. Rao said. The ACR abstracts are available online at the conference website . here. The MAXIMISE study (ClinicalTrials.gov Identifier: NCT02721966) found secukinumab to be effective in patients with axial PsA, so it may not really matter to differentiate between the 2 conditions in day-to-day practice. SELECT – PsA 1 was a study conducted among biologic-naive patients with PsA, and SELECT – PsA 2 was conducted among patients with PsA who had an inadequate response to treatment with a tumor necrosis factor (TNF) inhibitor. The researchers indicated that methotrexate seems to have good efficacy in PsA, although the study had limitations because there was no placebo and it could be claimed that the methotrexate response was because of the placebo. Friday, November 6, 2020; Poster Hall Hours | 9:00 - 11:00 AM Eastern Time; 9:00 AM – 11:00 AM ET. The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. Program and Faculty are updated daily - check back often for the most up-to-date information. Get stock quotes, news, fundamentals and easy to read SEC and SEDI insider filings. Ellen M. Gravallese, MD, chief of the Brigham’s Division of Rheumatology, Inflammation, and Immunity, gave the Presidential Address upon completion of her term as ACR president, expounding on the inspiring response of ACR members to the COVID-19 pandemic. Sign in If treatment with the TNF inhibitor fails, the class could be changed if it were a primary failure, and it can remain in the same class if it were a secondary failure. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; ACR Convergence 2020 . Researchers of the 2 guselkumab 1-year trials pooled data and studied patients who had axial symptoms and evidence of imaging-based sacroiliitis. ACR CONVERGENCE 2020— Earlier this year, the ACR released an updated guideline for the management of gout, and approximately 50 abstracts of studies on various aspects of gout were accepted for presentation at ACR Convergence 2020. There is a hierarchy to follow depending on the severity of the patient’s PsA. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster presentations. One would also take into account whether there is significant skin involvement, as we know that IL-17 and IL-23 inhibitors are superior to TNF inhibitors with respect to the skin. So, symmetric vs asymmetric sacroiliitis and thin vs chunky syndesmophytes would be 1 way of differentiating between axial PsA and axial SpA. In clinical practice, I believe that this distinction may not matter that much, as both TNF and IL-17 inhibitors would probably work on both conditions. This team targeted schnurri3 (Shn3) — a large, intracellular protein upregulated by TNF and IL-17A and known to be a suppressor of osteoblast activity — in specific bone cells in several mouse models of RA and determined its therapeutic potential in RA-induced bone loss. As I mentioned earlier, there are head-to-head studies showing that IL-17 inhibitors are as effective as TNF inhibitors; they are noninferior and superior in the skin. Sorry, your blog cannot share posts by email. It is thought that IL-23 inhibitors have no effect on the axial skeleton based on 2 studies: the first one included risankizumab, another IL-23 p19 inhibitor, and the second one was on ustekinumab, an IL-12/23 inhibitor. The study assessed whether the combination of methotrexate and etanercept was superior to etanercept alone. - Full-Length Features ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting ; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. However, radiographic examination of these patients will demonstrate symmetric sacroiliitis. The study highlights the power of single-cell transcriptomics in identifying cellular and molecular changes in organ tissues affected by inflammatory diseases. Results of the SEAM study (Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis; ClinicalTrials.gov Identifier: NCT02376790) were published last year and presented at the 2019 ACR annual meeting. Long-term outcomes with filgotinib, an oral selective Janus kinase 1 inhibitor: 100-week data from an open-label extension (OLE) study in patients with active psoriatic arthritis (PsA). If these patients have syndesmophytes, they are thin and run from the lower end of a vertebra to the upper end of the lower vertebra. Mease P, Deodhar A, van der Heijde D, et al. “If we heed these lessons and implement change thoughtfully, rheumatology will enter a new era as an even more essential and highly sought-after specialty,” she said in her speech. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. Efficacy of guselkumab, a monoclonal antibody that specifically binds to the p19 subunit of il-23, on axial-related endpoints in patients with active psa with imaging-confirmed sacroiliitis: week-52 results from two phase 3, randomized, double-blind, placebo-controlled studies. Here is a flavour of my read through … Pages: 1-4231; First Published: 09 November 2020; Abstract; PDF; Request permissions; Tools. There is a lot of work being conducted on standardizing the terminology for pre-PsA. - Drug Monographs At 5 years, it became challenging to identify what the risk factors were, although 1 risk factor that stood out was nail disease at baseline, which was something we already knew. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. The study concluded that there is a high burden of these needs among medically and psychosocially complex patients with lupus and that iCMP can successfully uncover and begin to address these barriers to care. November 5-9, 2020… Presented at: ACR Convergence 2020; November 5-9, 2020. Abstract 305. Efficacy of upadacitinib in patients with psoriatic arthritis stratified by number of prior biologic disease-modifying anti-rheumatic drugs. All Days; Wed, Nov 4; Thu, Nov 5; Fri, Nov 6; Sat, Nov 7; Sun, Nov 8; Mon, Nov 9; Tue, Nov 10; Sat, Nov 21; Full Schedule - ACR Convergence 2020. There were many studies that addressed “pre-PsA,” similar to pre-RA in patients with some arthralgias and a positive cyclic citrullinated peptide (CCP) test. Kevin S. Wei, MD, PhD; Ilya Korsunsky, PhD; Jennifer L. Marshall, PhD; Gerald F.M. Thanks for visiting Rheumatology Advisor. Presented at: ACR Convergence 2020; November 5-9, 2020. The ACR50/70 responses with deucravacitinib 6 and 12 mg per day administered orally were found to be superior to placebo. Michael B. Brenner, MD, was named an ACR Master, which recognizes “outstanding contributions to the ACR and the field of rheumatology through scholarly achievement and/or service to their patients, students, and profession.” In addition, Daniel Hal Solomon, MD, MPH, was given the Excellence in Investigative Mentoring Award, which honors “contributions to the rheumatology profession through outstanding and ongoing mentoring.”. Information from the ACR presentations are under embargo until November 5, 2020 … Presented at: ACR Convergence 2020; November 5-9, 2020. Therapies to induce immune responses against tumors, such as anti-PD-1 antibodies, have revolutionized the treatment of many cancers. They also evaluated individual components of BASDAI.4 These findings are quite interesting and make us think that perhaps axial PsA is different than axial SpA. They assessed changes in BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), and, when guselkumab was compared to placebo, there was a statistically significant difference. Their observation suggests that synovial endothelial cells, rather than being passive conduits of blood flow, orchestrate tissue remodeling through secretion of paracrine morphogenic signals. We hope you’re enjoying the latest clinical news, full-length features, case studies, and more. “This year’s Convergence conference was an historic event, as it was the first fully virtual meeting of the college,” Dr. Gravallese concluded. Currently, there is no good way of defining axial PsA, although the Assessment of SpA International Society (ASAS) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) are conducting a larger international study, the Axial Involvement in PsA Cohort (AXIS) study (ClinicalTrials.gov Identifier: NCT04434885), to define axial PsA and how to quantify these patients. Abstract LO3. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster … Your use of this website constitutes acceptance of Haymarket Media’s Privacy Policy and Terms & Conditions. In the United States, unfortunately, treatment also depends on what the insurance company will approve and patients’ out-of-pocket expenses. Abstract 907. Dr Saakshi Khattri reviews key abstracts about psoriatic arthritis from the annual ACR meeting, including a tool for early detection and a study showing dactylitis may signal an aggressive phenotype. The increasing availability of detailed electronic health record data, along with methods such as machine learning and natural language processing (NLP), provide an opportunity to streamline our ability to find these patients. … Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1460 “Can I … All Days ; Wed, Nov 4; Thu, Nov 5; Fri, Nov 6; Sat, Nov 7; Sun, Nov 8; Mon, Nov 9; Tue, Nov 10; Sat, Nov 21; Full Schedule - ACR Convergence 2020. RA is a chronic inflammatory disease that leads to local and systemic bone loss. Already have an account? Approximately 6% to 7% of patients with AS have psoriasis as well. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . Don’t miss out on today’s top content on Rheumatology Advisor. Accepted Late-Breaking abstracts will be available late October. The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. Gravallese and Solomon lamented the inability to interact directly with fellow participants but noted an upside: About 16,400 people from 111 countries attended at least some portion of the conference, compared with the typical 9,000 to 10,000 attendees. We are now also observing that guselkumab, at least according to the results of DISCOVER-1 (ClinicalTrials.gov Identifier: NCT03162796) and DISCOVER-2 (ClinicalTrials.gov Identifier: NCT03158285) trials, has been found to have a strikingly good safety profile. Drs. For many clinical trials in rheumatology, identifying eligible patients is a labor-intensive and rate-limiting step. Data that will contribute to our decision-making may include considering the severity of musculoskeletal disease, the severity of skin disease, and the safety of the treatment. They also aimed to understand whether social determinants of health-related needs such as food insecurity, housing instability and financial constraints were prevalent among patients with lupus enrolled in iCMP. There are also several types of drugs and there are many different classes of each drug: conventional synthetic disease-modifying antirheumatic drugs (DMARDs); TNF inhibitors (there are 5 of them); the IL-12/23 inhibitor (ustekinumab); IL-17 inhibitors (secukinumab and ixekizumab); pure IL-23 inhibitors (there are 3 of them; 1 has been approved for PsA [guselkumab], but rizankizumab and tildrakizumab are being studied in phase 2 trials presented at the ACR 2020 meeting); JAK inhibitors; the phosphodiesterase-4 (PDE4) inhibitor apremilast; and abatacept (a T-cell inhibitor that is mainly used for RA but has been approved for the treatment of PsA). There were several interesting abstracts presented at this year’s ACR annual meeting from a therapy standpoint, some of which were also presented at the 2020 European League Against Rheumatism (EULAR) annual meeting. Mease P, Helliwell P, Gladwell D, et al. Please login or register first to view this content. If it is more severe and there is involvement of numerous joints with polyarticular inflammation and skin involvement, you directly use a TNF inhibitor and avoid methotrexate. If the disease is mild, you can use methotrexate. Zheni Stavre, MD; JungMin Kim, PhD; Jae-Hyuck Shim, PhD; Ellen M. Gravallese, MD. You’ve viewed {{metering-count}} of {{metering-total}} articles this month. The surprise was that compared to adalimumab, which is a very good drug even for the skin, the response rate (Psoriasis Area and Severity Index [PASI] 90, PASI 100) with upadacitinib was found to be better than with adalimumab.1, The other abstract addressed upadacitinib in patients with inadequate response to TNF inhibitors; this study showed that patients with PsA demonstrated a good response to upadacitinib.2, Long-term data (week 52 and 100) from a study on another JAK1 inhibitor, filgotinib, showed that this drug works and maintains its efficacy in the long term. All times listed are Eastern Standard Time. Type here to filter the list. In axial PsA, patients typically have asymmetric sacroiliitis and “chunky,” asymmetric, osteophyte-looking changes in the spine that run from the middle of the vertebra to the next vertebra. The real clinical question is how to differentiate between a patient who has ankylosing spondylitis (AS) with skin psoriasis and a patient who has PsA and axial symptoms. Type here to filter the list. Mease P, Lertratanakul A, Strober B, et al. Program and Faculty are updated daily - check back often for the most up-to-date information. ACR CONVERGENCE 2020—The field of rheumatology is vast, with innumerable diseases to consider in each differential and with myriad possible presentations of each condition. Click to share on LinkedIn (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to email this to a friend (Opens in new window), Virtual Visits Accelerate Urology Patient Care, Optimizing Care for Every Patient With Genitourinary Cancer. Presented at: ACR Convergence 2020; November 5-9, 2020. Shared decision-making is very important. Last year, ACR and the National Psoriasis Foundation (NPF) published treatment guidelines, which are the latest guidelines available to us. This site features news for physicians about research, innovation and clinical care at Brigham and Women’s Hospital. Presented at: ACR Convergence 2020; November 5-9, 2020. ACR CONVERGENCE 2020—Moderated by Bill St.Clair, MD, MACR, an ACR past president and a professor of medicine and immunology at Duke University Medical Center, Durham, N.C., an abstract session on Friday, Nov. 6, focused on the diagnosis, manifestations and outcomes of rheumatoid arthritis (RA), with a focus on interstitial lung disease. In this study, the team performed single-cell transcriptomic analysis (scRNAseq) of synovial vasculature to characterize vascular remodeling at a single-cell level. The following is a look at five abstracts presented by Brigham physicians and scientists. Approximately 80% of patients with AS have the HLA-B27 gene, and only approximately 50% of patients with axial PsA have the HLA-B27. The ACR abstracts are available online at the conference website.Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. Full Schedule - 2020 ACR Convergence. Enjoying our content? Dr. Liao’s team developed an algorithm using machine learning and NLP that reduced the number of charts requiring review by 40–45 percent compared to reviewing any subjects with an ICD code for rheumatoid arthritis (RA). Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you At week 52, all patients remaining on ADL-EU were switched to ADL-PF. The investigators also looked at enthesitis resolution, minimal disease activity, and Health Assessment Questionnaire Disability Index. This is where the treatment guidelines are very important. Kiniksa Announces American College of Rheumatology Convergence 2020 Late-Breaking Abstracts Presentation of Mavrilimumab Phase 2 Giant Cell … Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1879. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. JAK inhibitors have been approved for the treatment of rheumatoid arthritis (RA), and we know that they are fairly good with respect to the peripheral joints because of our experience with them in RA. New agents for PsA, we do have a biomarker, and discussing select posters. 2 guselkumab 1-year trials pooled data and studied patients who received methotrexate alone the team performed single-cell analysis! Of patients with as have psoriasis as well, it wasn ’ t out. 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